Abstract
Desferrioxamine (DFO) has been widely used as a specific iron chelator. In this study, the non-chelation dependent redox actions of DFO were demonstrated. The protection by DFO against DNA scission caused by tetrachlorohydroquinone arises from a reaction between tetrachlorosemiquinone radical and DFO which yields a DFO nitroxide free radical. DFO was also found to enhance dechlorination of tetrachloro-1,4-benzoquinone. These results suggest two additional mechanisms through which DFO might have effects on biological oxidation reactions.
| Original language | American English |
|---|---|
| Title of host publication | Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Significance |
| Editors | Tomris Özben |
| Place of Publication | Boston, MA |
| Publisher | Springer US; Imprint: Springer |
| Pages | 15-24 |
| Number of pages | 10 |
| ISBN (Print) | 978-1-4757-2907-8 |
| DOIs | |
| State | Published - 1998 |