Non-Chelation Dependent Redox Actions of Desferrioxamine

Ben-Zhan Zhu; Ronit Har-El; Nahum Kitrossky; Mordechai Chevion

doi:10.1007/978-1-4757-2907-8_2

Non-Chelation Dependent Redox Actions of Desferrioxamine

Ben-Zhan Zhu
, Ronit Har-El
, Nahum Kitrossky
, Mordechai Chevion

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Desferrioxamine (DFO) has been widely used as a specific iron chelator. In this study, the non-chelation dependent redox actions of DFO were demonstrated. The protection by DFO against DNA scission caused by tetrachlorohydroquinone arises from a reaction between tetrachlorosemiquinone radical and DFO which yields a DFO nitroxide free radical. DFO was also found to enhance dechlorination of tetrachloro-1,4-benzoquinone. These results suggest two additional mechanisms through which DFO might have effects on biological oxidation reactions.

Original language	American English
Title of host publication	Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Significance
Editors	Tomris Özben
Place of Publication	Boston, MA
Publisher	Springer US; Imprint: Springer
Pages	15-24
Number of pages	10
ISBN (Print)	978-1-4757-2907-8
DOIs	https://doi.org/10.1007/978-1-4757-2907-8_2
State	Published - 1998

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10.1007/978-1-4757-2907-8_2

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title = "Non-Chelation Dependent Redox Actions of Desferrioxamine",

abstract = "Desferrioxamine (DFO) has been widely used as a specific iron chelator. In this study, the non-chelation dependent redox actions of DFO were demonstrated. The protection by DFO against DNA scission caused by tetrachlorohydroquinone arises from a reaction between tetrachlorosemiquinone radical and DFO which yields a DFO nitroxide free radical. DFO was also found to enhance dechlorination of tetrachloro-1,4-benzoquinone. These results suggest two additional mechanisms through which DFO might have effects on biological oxidation reactions.",

author = "Ben-Zhan Zhu and Ronit Har-El and Nahum Kitrossky and Mordechai Chevion",

year = "1998",

doi = "10.1007/978-1-4757-2907-8\_2",

language = "American English",

isbn = "978-1-4757-2907-8",

pages = "15--24",

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TY - CHAP

T1 - Non-Chelation Dependent Redox Actions of Desferrioxamine

AU - Zhu, Ben-Zhan

AU - Har-El, Ronit

AU - Kitrossky, Nahum

AU - Chevion, Mordechai

PY - 1998

Y1 - 1998

N2 - Desferrioxamine (DFO) has been widely used as a specific iron chelator. In this study, the non-chelation dependent redox actions of DFO were demonstrated. The protection by DFO against DNA scission caused by tetrachlorohydroquinone arises from a reaction between tetrachlorosemiquinone radical and DFO which yields a DFO nitroxide free radical. DFO was also found to enhance dechlorination of tetrachloro-1,4-benzoquinone. These results suggest two additional mechanisms through which DFO might have effects on biological oxidation reactions.

AB - Desferrioxamine (DFO) has been widely used as a specific iron chelator. In this study, the non-chelation dependent redox actions of DFO were demonstrated. The protection by DFO against DNA scission caused by tetrachlorohydroquinone arises from a reaction between tetrachlorosemiquinone radical and DFO which yields a DFO nitroxide free radical. DFO was also found to enhance dechlorination of tetrachloro-1,4-benzoquinone. These results suggest two additional mechanisms through which DFO might have effects on biological oxidation reactions.

U2 - 10.1007/978-1-4757-2907-8_2

DO - 10.1007/978-1-4757-2907-8_2

M3 - Chapter

SN - 978-1-4757-2907-8

SP - 15

EP - 24

BT - Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Significance

A2 - Özben, Tomris

PB - Springer US; Imprint: Springer

CY - Boston, MA

ER -

Non-Chelation Dependent Redox Actions of Desferrioxamine

Abstract

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