Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat

Michal Horowitz; Omer Cohen; Yonathan Hasin; Alina Maloyan; Einat Levi

doi:10.1007/978-1-4615-0453-5_36

Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat

Michal Horowitz, Omer Cohen, Yonathan Hasin, Alina Maloyan, Einat Levi

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Heat acclimation produces concerted favorable adaptations in the mechanical and metabolic performance of the heart. Under normoxic condition this is displayed primarily by greater pressure generation with lower oxygen consumption. Altered expression of calcium regulatory proteins, EC coupling proteins and redistribution of the myosin isoenzyme to predominancy of the V3 isoform contribute to the changes observed. An important acclimatory response is the finding that heat acclimation confers protection against ischemic/reperfusion insults. This is due to numerous factors among which greater constitutive HSP 72kDA (Δ200%) reserves and energy sparing mechanisms such as redistribution of ATPase isoforms and altered glycolytic flux leading to better intracellular pH concomitantly with continuous ATP production, are likely candidates. Collectively, our data indicate that both transcriptional and post-transcriptional processes are involved and underline the integrative response.

Original language	American English
Title of host publication	Pathophysiology of Cardiovascular Disease
Editors	Naranjan S. Dhalla, Heinz Rupp, Aubie Angel, Grant N. Pierce
Place of Publication	Boston, MA
Publisher	Springer US; Imprint: Springer
Pages	525-533
Number of pages	9
ISBN (Print)	978-1-4615-0453-5
DOIs	https://doi.org/10.1007/978-1-4615-0453-5_36
State	Published - 2004

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10.1007/978-1-4615-0453-5_36

Cite this

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title = "Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat",

abstract = "Heat acclimation produces concerted favorable adaptations in the mechanical and metabolic performance of the heart. Under normoxic condition this is displayed primarily by greater pressure generation with lower oxygen consumption. Altered expression of calcium regulatory proteins, EC coupling proteins and redistribution of the myosin isoenzyme to predominancy of the V3 isoform contribute to the changes observed. An important acclimatory response is the finding that heat acclimation confers protection against ischemic/reperfusion insults. This is due to numerous factors among which greater constitutive HSP 72kDA (Δ200%) reserves and energy sparing mechanisms such as redistribution of ATPase isoforms and altered glycolytic flux leading to better intracellular pH concomitantly with continuous ATP production, are likely candidates. Collectively, our data indicate that both transcriptional and post-transcriptional processes are involved and underline the integrative response.",

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language = "American English",

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editor = "Dhalla, {Naranjan S.} and Heinz Rupp and Aubie Angel and Pierce, {Grant N.}",

booktitle = "Pathophysiology of Cardiovascular Disease",

publisher = "Springer US; Imprint: Springer",

}

Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat. / Horowitz, Michal; Cohen, Omer; Hasin, Yonathan et al.
Pathophysiology of Cardiovascular Disease. ed. / Naranjan S. Dhalla; Heinz Rupp; Aubie Angel; Grant N. Pierce. Boston, MA: Springer US; Imprint: Springer, 2004. p. 525-533.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat

AU - Horowitz, Michal

AU - Cohen, Omer

AU - Hasin, Yonathan

AU - Maloyan, Alina

AU - Levi, Einat

PY - 2004

Y1 - 2004

N2 - Heat acclimation produces concerted favorable adaptations in the mechanical and metabolic performance of the heart. Under normoxic condition this is displayed primarily by greater pressure generation with lower oxygen consumption. Altered expression of calcium regulatory proteins, EC coupling proteins and redistribution of the myosin isoenzyme to predominancy of the V3 isoform contribute to the changes observed. An important acclimatory response is the finding that heat acclimation confers protection against ischemic/reperfusion insults. This is due to numerous factors among which greater constitutive HSP 72kDA (Δ200%) reserves and energy sparing mechanisms such as redistribution of ATPase isoforms and altered glycolytic flux leading to better intracellular pH concomitantly with continuous ATP production, are likely candidates. Collectively, our data indicate that both transcriptional and post-transcriptional processes are involved and underline the integrative response.

AB - Heat acclimation produces concerted favorable adaptations in the mechanical and metabolic performance of the heart. Under normoxic condition this is displayed primarily by greater pressure generation with lower oxygen consumption. Altered expression of calcium regulatory proteins, EC coupling proteins and redistribution of the myosin isoenzyme to predominancy of the V3 isoform contribute to the changes observed. An important acclimatory response is the finding that heat acclimation confers protection against ischemic/reperfusion insults. This is due to numerous factors among which greater constitutive HSP 72kDA (Δ200%) reserves and energy sparing mechanisms such as redistribution of ATPase isoforms and altered glycolytic flux leading to better intracellular pH concomitantly with continuous ATP production, are likely candidates. Collectively, our data indicate that both transcriptional and post-transcriptional processes are involved and underline the integrative response.

U2 - 10.1007/978-1-4615-0453-5_36

DO - 10.1007/978-1-4615-0453-5_36

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SN - 978-1-4615-0453-5

SP - 525

EP - 533

BT - Pathophysiology of Cardiovascular Disease

A2 - Dhalla, Naranjan S.

A2 - Rupp, Heinz

A2 - Angel, Aubie

A2 - Pierce, Grant N.

PB - Springer US; Imprint: Springer

CY - Boston, MA

ER -

Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat

Abstract

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