TY - JOUR
T1 - Non-immune non-activated chicken macrophage destroy murine fibroblast
AU - Gallily, R.
AU - Stain, I.
AU - Kornfeld, S.
PY - 1985
Y1 - 1985
N2 - Non-immune non-activated chicken bone marrow-derived macrophages (BM MØ) killed murine embryonic fibroblasts in vitro. Following precultivation for 10-35 days chicken BM MØ had the capacity to destroy normal murine embryonic fibroblasts at effector: target ratios of 10:1 to 1:1. Optimal killing was observed following cocultivation of MØ and fibroblasts for 48-72 hrs. Addition of LPS neither initiated nor potentiated MØ-mediated killing. This study demonstrates that chicken MØ have the capacity to destroy, in vitro, cells of phylogenetically distant species, similarly to the ability of murine MØ to kill chicken fibroblasts. It is suggested that vertebrate MØ xenolytic potential is analagous to the capacity of invertebrate phagocytes to destroy xenografts.
AB - Non-immune non-activated chicken bone marrow-derived macrophages (BM MØ) killed murine embryonic fibroblasts in vitro. Following precultivation for 10-35 days chicken BM MØ had the capacity to destroy normal murine embryonic fibroblasts at effector: target ratios of 10:1 to 1:1. Optimal killing was observed following cocultivation of MØ and fibroblasts for 48-72 hrs. Addition of LPS neither initiated nor potentiated MØ-mediated killing. This study demonstrates that chicken MØ have the capacity to destroy, in vitro, cells of phylogenetically distant species, similarly to the ability of murine MØ to kill chicken fibroblasts. It is suggested that vertebrate MØ xenolytic potential is analagous to the capacity of invertebrate phagocytes to destroy xenografts.
UR - http://www.scopus.com/inward/record.url?scp=0022348549&partnerID=8YFLogxK
U2 - 10.1016/0145-305X(85)90033-3
DO - 10.1016/0145-305X(85)90033-3
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C2 - 4085676
AN - SCOPUS:0022348549
SN - 0145-305X
VL - 9
SP - 691
EP - 699
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 4
ER -