Non-Immunological Recognition and Killing of Xenogeneic Cells by Macrophages: III Destruction of Fish Cells by Murine Macrophages

R. Gallily; A. Yamin; R. R. Caspi; R. R. Avtalion

doi:10.1016/S0145-305X(82)80043-8

Non-Immunological Recognition and Killing of Xenogeneic Cells by Macrophages: III Destruction of Fish Cells by Murine Macrophages

R. Gallily^*, A. Yamin, R. R. Caspi, R. R. Avtalion

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Non-immune non-activated murine peritoneal macrophages killed in vitro fish (Cyprinus carpio) PHA-induced lymphoblasts. Addition of PHA and WGA to effector-target cell cultures did not potentiate the killing. This killing (xenolysis) was expressed by non-elicited and thioglycollate-elicited macrophages as well as by macrophages depleted of lymphocytes. It is suggested that mammalian macrophages have a xenolytic potential towards phylogenetically distant species which is analogous to the capacity of invertebrate phagocytes to destroy xenografts.

Original language	English
Pages (from-to)	569-578
Number of pages	10
Journal	Topics in Catalysis
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/S0145-305X(82)80043-8
State	Published - 1982

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title = "Non-Immunological Recognition and Killing of Xenogeneic Cells by Macrophages: III Destruction of Fish Cells by Murine Macrophages",

abstract = "Non-immune non-activated murine peritoneal macrophages killed in vitro fish (Cyprinus carpio) PHA-induced lymphoblasts. Addition of PHA and WGA to effector-target cell cultures did not potentiate the killing. This killing (xenolysis) was expressed by non-elicited and thioglycollate-elicited macrophages as well as by macrophages depleted of lymphocytes. It is suggested that mammalian macrophages have a xenolytic potential towards phylogenetically distant species which is analogous to the capacity of invertebrate phagocytes to destroy xenografts.",

author = "R. Gallily and A. Yamin and Caspi, \{R. R.\} and Avtalion, \{R. R.\}",

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AU - Caspi, R. R.

AU - Avtalion, R. R.

PY - 1982

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AB - Non-immune non-activated murine peritoneal macrophages killed in vitro fish (Cyprinus carpio) PHA-induced lymphoblasts. Addition of PHA and WGA to effector-target cell cultures did not potentiate the killing. This killing (xenolysis) was expressed by non-elicited and thioglycollate-elicited macrophages as well as by macrophages depleted of lymphocytes. It is suggested that mammalian macrophages have a xenolytic potential towards phylogenetically distant species which is analogous to the capacity of invertebrate phagocytes to destroy xenografts.

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Non-Immunological Recognition and Killing of Xenogeneic Cells by Macrophages: III Destruction of Fish Cells by Murine Macrophages

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