TY - JOUR
T1 - Non-invasive forced expiratory flow-volume curves to measure lung function in cats
AU - Bark, Hylton
AU - Epstein, Ana
AU - Bar-Yishay, Ephraim
AU - Putilov, Alex
AU - Godfrey, Simon
PY - 2007/1/15
Y1 - 2007/1/15
N2 - Forced expiratory flow-volume curves were performed in 15 cats using the non-invasive thoracic compression techniques developed for use in human infants. Cats breathed through a face mask and pneumotachygraph from which flow and volume were obtained. Thoracic compression was applied from an inflatable bag in a non-expandable jacket surrounding the animal. Bag inflation at end inspiration was initiated by a computer pulse to a pressurized chamber. Processed signals from the pneumotachygraph determined maximum-forced expiratory flow at lung volume equivalent to functional residual capacity (FRC), termed V′maxFRC. Different compression pressures were used, and the highest value from a technically satisfactory flow-volume loop was taken as the result. Mean (±95% CI) V′maxFRC was 422 (369-475) ml/s. Compared with infants of similar weight (V′maxFRC approximately 180 ml/s), cats had a much higher V′maxFRC. Tests repeated another day showed a mean (±95% CI) percentage difference between paired tests to be 2.8 (-12.6, +18.3)%. Non-invasive forced expiratory flow-volume measurements can be reliably obtained in sedated cats.
AB - Forced expiratory flow-volume curves were performed in 15 cats using the non-invasive thoracic compression techniques developed for use in human infants. Cats breathed through a face mask and pneumotachygraph from which flow and volume were obtained. Thoracic compression was applied from an inflatable bag in a non-expandable jacket surrounding the animal. Bag inflation at end inspiration was initiated by a computer pulse to a pressurized chamber. Processed signals from the pneumotachygraph determined maximum-forced expiratory flow at lung volume equivalent to functional residual capacity (FRC), termed V′maxFRC. Different compression pressures were used, and the highest value from a technically satisfactory flow-volume loop was taken as the result. Mean (±95% CI) V′maxFRC was 422 (369-475) ml/s. Compared with infants of similar weight (V′maxFRC approximately 180 ml/s), cats had a much higher V′maxFRC. Tests repeated another day showed a mean (±95% CI) percentage difference between paired tests to be 2.8 (-12.6, +18.3)%. Non-invasive forced expiratory flow-volume measurements can be reliably obtained in sedated cats.
KW - Feline
KW - Forced expiratory flow-volume curves
KW - V
UR - http://www.scopus.com/inward/record.url?scp=33845986366&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2006.03.005
DO - 10.1016/j.resp.2006.03.005
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C2 - 16621733
AN - SCOPUS:33845986366
SN - 1569-9048
VL - 155
SP - 49
EP - 54
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 1
ER -