Nonimmunogenic radiation induced lymphoma immunity induction by a somatic cell hybrid

Eitan Yefenof*, Mira Goldapfel, Rosalie Ber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The cell line designated PIR-2 is a nonimmunogenic X ray-induced thymoma of C57BL/6 origin that is unable to induce antitumor immunity in syngeneic lymphocytes in vitro and in mice in vivo, Fusion of PIR-2 with an allogeneic "universal fuser', A9HT (clone 3c) resulted in the establishment of a somatic cell hybrid designated A9/PIR. C57BL/6 lymphocytes sensitized in vitro with A9/PIR could lyse parental PIR-2 cells, as well as other syngeneic tumors. However, immunization of mice with the hybrid significantly enhanced PIR-2 tumor takes while it partially protected the animals against a challenge with unrelated syngeneic tumors. The results imply that somatic cell hybridization can increase the immunogenicity of an otherwise nonim­ munogenic tumor. However, in view of the enhancing effects of hybrid preimmunization on parental tumor cell growth, the possible application of this approach for immunotherapy is questionabl.

Original languageEnglish
Pages (from-to)841-849
Number of pages9
JournalJournal of the National Cancer Institute
Volume68
Issue number5
DOIs
StatePublished - May 1982

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