Nonparametric estimation of transition probabilities for a general progressive multi-state model under cross-sectional sampling

Jacobo de Uña-Álvarez*, Micha Mandel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Nonparametric estimation of the transition probability matrix of a progressive multi-state model is considered under cross-sectional sampling. Two different estimators adapted to possibly right-censored and left-truncated data are proposed. The estimators require full retrospective information before the truncation time, which, when exploited, increases efficiency. They are obtained as differences between two survival functions constructed for sub-samples of subjects occupying specific states at a certain time point. Both estimators correct the oversampling of relatively large survival times by using the left-truncation times associated with the cross-sectional observation. Asymptotic results are established, and finite sample performance is investigated through simulations. One of the proposed estimators performs better when there is no censoring, while the second one is strongly recommended with censored data. The new estimators are applied to data on patients in intensive care units (ICUs).

Original languageAmerican English
Pages (from-to)1203-1212
Number of pages10
JournalBiometrics
Volume74
Issue number4
DOIs
StatePublished - Dec 2018

Bibliographical note

Publisher Copyright:
© 2018, The International Biometric Society

Keywords

  • Biased data
  • Illness-death model
  • Inverse weighting
  • Left truncation
  • Multi-state models

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