Noradrenaline releasing effect of an ouabain-like compound on pulmonary artery

E. S. Vizi; F. Oberfrank; S. Bernath; D. Lichtstein

doi:10.1016/0028-3908(87)90177-8

Noradrenaline releasing effect of an ouabain-like compound on pulmonary artery

E. S. Vizi^*, F. Oberfrank, S. Bernath, D. Lichtstein

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The effect of ouabain and an endogenous ouabain-like compound (OLC) was studied on (3H)noradrenaline ((3H)NA) release from rabbit pulmonary artery. Similarly to ouabain, OLC enhanced the release of (3H)NA in response to electrical stimulation. These findings are the first evidence that OLC is able to act presynaptically and enhance the amount of (3H)NA release per impulse. It is suggested that this mechanism might be involved in the physiological regulation of blood pressure or in the genesis of hypertension.

Original language	English
Pages (from-to)	1541-1544
Number of pages	4
Journal	Neuropharmacology
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/0028-3908(87)90177-8
State	Published - Oct 1987

Keywords

NaK-ATPase
hypertension
noradrenaline release
ouabain-like compound
presynaptic modulation

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10.1016/0028-3908(87)90177-8

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abstract = "The effect of ouabain and an endogenous ouabain-like compound (OLC) was studied on (3H)noradrenaline ((3H)NA) release from rabbit pulmonary artery. Similarly to ouabain, OLC enhanced the release of (3H)NA in response to electrical stimulation. These findings are the first evidence that OLC is able to act presynaptically and enhance the amount of (3H)NA release per impulse. It is suggested that this mechanism might be involved in the physiological regulation of blood pressure or in the genesis of hypertension.",

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AU - Lichtstein, D.

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AB - The effect of ouabain and an endogenous ouabain-like compound (OLC) was studied on (3H)noradrenaline ((3H)NA) release from rabbit pulmonary artery. Similarly to ouabain, OLC enhanced the release of (3H)NA in response to electrical stimulation. These findings are the first evidence that OLC is able to act presynaptically and enhance the amount of (3H)NA release per impulse. It is suggested that this mechanism might be involved in the physiological regulation of blood pressure or in the genesis of hypertension.

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KW - noradrenaline release

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KW - presynaptic modulation

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Noradrenaline releasing effect of an ouabain-like compound on pulmonary artery

Abstract

Keywords

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