NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus

Que Chi Truong-Bolduc, Jacob Strahilevitz, David C. Hooper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.

Original languageAmerican English
Pages (from-to)1104-1107
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

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