NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus

Que Chi Truong-Bolduc; Jacob Strahilevitz; David C. Hooper

doi:10.1128/AAC.50.3.1104-1107.2006

NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus

Que Chi Truong-Bolduc
, Jacob Strahilevitz
, David C. Hooper^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.

Original language	English
Pages (from-to)	1104-1107
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	3
DOIs	https://doi.org/10.1128/AAC.50.3.1104-1107.2006
State	Published - Mar 2006
Externally published	Yes

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10.1128/AAC.50.3.1104-1107.2006

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title = "NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus",

abstract = "NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.",

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AU - Hooper, David C.

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AB - NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.

UR - https://www.scopus.com/pages/publications/33644647334

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NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus

Abstract

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