Normal and Transforming N-Terminal Variants of c-abl

Yinon Ben-Neriah, David Baltimore

Research output: Chapter in Book/Report/Conference proceedingChapter


V-abl was first described as the oncogene contained in Abelson murine leukemia virus (A-MuLV), a virus that transforms both lymphocytes and fibroblast lines. The v-abl gene product has a protein tyrosine kinase activity which is essential for the transforming capacity of the virus (Prywes et al. 1983). The normal cellular counterpart, the c-abl proto-oncogene, also encodes a protein with tyrosine kinase activity (Konopka and Witte 1985; Ben-Neriah et al. 1986a). In addition to capture by retroviruses, c-abl can be activated by chromosomal translocations, such as in human chronic myeloid leukemia. In this review we discuss the structure of the c-abl gene, the various transcripts it expresses, and how it is activated to become an oncogene.
Original languageEnglish
Title of host publicationOncogenes and Growth Control
EditorsPatricia Kahn, Thomas Graf
Place of PublicationBerlin, Heidelberg
PublisherSpringer Berlin Heidelberg
Number of pages9
ISBN (Electronic)978-3-642-73325-3
ISBN (Print)978-3-540-18760-8
StatePublished - 1986


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