Notice of Removal: Ultrasound-mediated transfection of endogenous stem cells for regenerative medicine

Maxim Bez; Dmitriy Sheyn; Wafa Tawackoli; Pablo Avalos; Galina Shapiro; Joseph Giaconi; Xiaoyu Da; Shiran Bendavid; Jayne Gavrity; Hani Awad; Hyun Bae; Eric Ley; Thomas Kremen; Zulma Gazit; Katherine Ferrara; Gadi Pelled; Dan Gazit

doi:10.1109/ULTSYM.2017.8092153

Notice of Removal: Ultrasound-mediated transfection of endogenous stem cells for regenerative medicine

Maxim Bez
, Dmitriy Sheyn
, Wafa Tawackoli
, Pablo Avalos
, Galina Shapiro
, Joseph Giaconi
, Xiaoyu Da
, Shiran Bendavid
, Jayne Gavrity
, Hani Awad
, Hyun Bae
, Eric Ley
, Thomas Kremen
, Zulma Gazit
, Katherine Ferrara
, Gadi Pelled
, Dan Gazit

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The oscillation of microbubbles has long been hypothesized to provide the opportunity to enhance gene delivery as a result of changes in membrane permeability; however, translationally-relevant therapeutic protocols have not yet been realized. We sought to develop and validate a protocol to transfect endogenous mesenchymal stem cells (MSCs) via the local injection of plasmids and microbubbles and the application of ultrasound. We apply this therapy in a pre-clinical model to solve an important clinical problem - that of healing segmental bone defects. More than two million bone-grafting procedures are performed each year using autografts or allografts and these standard of care therapies have substantial disadvantages.

Original language	English
Title of host publication	2017 IEEE International Ultrasonics Symposium, IUS 2017
Publisher	IEEE Computer Society
ISBN (Electronic)	9781538633830
DOIs	https://doi.org/10.1109/ULTSYM.2017.8092153
State	Published - 31 Oct 2017
Externally published	Yes
Event	2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: 6 Sep 2017 → 9 Sep 2017

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
Volume	0
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/Territory	United States
City	Washington
Period	6/09/17 → 9/09/17

Bibliographical note

Publisher Copyright:
© 2017 IEEE.

Access to Document

10.1109/ULTSYM.2017.8092153

Cite this

Bez, M., Sheyn, D., Tawackoli, W., Avalos, P., Shapiro, G., Giaconi, J., Da, X., Bendavid, S., Gavrity, J., Awad, H., Bae, H., Ley, E., Kremen, T., Gazit, Z., Ferrara, K., Pelled, G., & Gazit, D. (2017). Notice of Removal: Ultrasound-mediated transfection of endogenous stem cells for regenerative medicine. In 2017 IEEE International Ultrasonics Symposium, IUS 2017 Article 8092153 (IEEE International Ultrasonics Symposium, IUS; Vol. 0). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2017.8092153

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title = "Notice of Removal: Ultrasound-mediated transfection of endogenous stem cells for regenerative medicine",

abstract = "The oscillation of microbubbles has long been hypothesized to provide the opportunity to enhance gene delivery as a result of changes in membrane permeability; however, translationally-relevant therapeutic protocols have not yet been realized. We sought to develop and validate a protocol to transfect endogenous mesenchymal stem cells (MSCs) via the local injection of plasmids and microbubbles and the application of ultrasound. We apply this therapy in a pre-clinical model to solve an important clinical problem - that of healing segmental bone defects. More than two million bone-grafting procedures are performed each year using autografts or allografts and these standard of care therapies have substantial disadvantages.",

author = "Maxim Bez and Dmitriy Sheyn and Wafa Tawackoli and Pablo Avalos and Galina Shapiro and Joseph Giaconi and Xiaoyu Da and Shiran Bendavid and Jayne Gavrity and Hani Awad and Hyun Bae and Eric Ley and Thomas Kremen and Zulma Gazit and Katherine Ferrara and Gadi Pelled and Dan Gazit",

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doi = "10.1109/ULTSYM.2017.8092153",

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Bez, M, Sheyn, D, Tawackoli, W, Avalos, P, Shapiro, G, Giaconi, J, Da, X, Bendavid, S, Gavrity, J, Awad, H, Bae, H, Ley, E, Kremen, T, Gazit, Z, Ferrara, K, Pelled, G & Gazit, D 2017, Notice of Removal: Ultrasound-mediated transfection of endogenous stem cells for regenerative medicine. in 2017 IEEE International Ultrasonics Symposium, IUS 2017., 8092153, IEEE International Ultrasonics Symposium, IUS, vol. 0, IEEE Computer Society, 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 6/09/17. https://doi.org/10.1109/ULTSYM.2017.8092153

Notice of Removal: Ultrasound-mediated transfection of endogenous stem cells for regenerative medicine. / Bez, Maxim; Sheyn, Dmitriy; Tawackoli, Wafa et al.
2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 2017. 8092153 (IEEE International Ultrasonics Symposium, IUS; Vol. 0).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ley, Eric

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AU - Gazit, Dan

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Notice of Removal: Ultrasound-mediated transfection of endogenous stem cells for regenerative medicine

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