Novaluron nanoparticles: Formation and potential use in controlling agricultural insect pests

Naomi Elek, Roy Hoffman, Uri Raviv, Roy Resh, Isaac Ishaaya, Shlomo Magdassi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Nanoparticles of novaluron, a water-insoluble insecticide, were prepared by a novel method, based on a direct conversion of O/W microemulsions containing pesticide and volatile solvents, into powders. The conversion of nanoparticles into powder was achieved by rapid evaporation of all the liquids in the microemulsion by spray drying. The microemulsions were evaluated by SAXS, self diffusion NMR, conductivity, and viscosity. The droplet size was approximately 6. nm, and the novaluron particle size, after redispersion and evaluation by DLS, was 200 ± 50. nm. These particles consisted of aggregates of nanoparticles (30-100. nm), as viewed by Cryo-TEM. Electron diffraction and XRD showed that the nanoparticles were amorphous indicating a possible improved bioactivity. The stability of the dispersed nanoparticles was evaluated by following particle size by DLS for a period of time, revealing a slight increase in particle size despite the high value of zeta potential. In vivo experiments carried out with Egyptian cotton leafworm Spodoptera littoralis larvae indicated that the toxicity of nanoparticles of novaluron resembled that of the commercial formulation.

Original languageAmerican English
Pages (from-to)66-72
Number of pages7
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Issue number1-3
StatePublished - 3 Dec 2010

Bibliographical note

Funding Information:
The authors are grateful to Prof. David Vaknin from Ames Laboratories, Department of Physics and Astronomy, Iowa University, for helpful discussions, to Makteshim-Agan for the donation of the Novaluron (Rimon) technical powder, to Beamline BM26B, at ESRF, Grenoble (France) for the SAXS measurements, and to the NFM Magnet program of the Israel Ministry of Industry for the financial support.


  • Biological activity
  • Microemulsion
  • Novaluron
  • Organic nanoparticles
  • Pesticides
  • Spray dryer


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