TY - JOUR
T1 - Novel Ca2+ channels underlying transduction in Drosophila photoreceptors
T2 - implications for phosphoinositide-mediated Ca2+ mobilization
AU - Hardie, R. C.
AU - Minke, B.
PY - 1993/9
Y1 - 1993/9
N2 - Drosophila photoreceptors are excellent models for studies of the ubiquitous phosphoinositide signalling cascade. Recent studies suggest that light-induced phosphoinositide hydrolysis in Drosophila leads to the activation of two classes of channels. One is selective for Ca2+ and absent in the transient receptor potential mutant trp. The trp gene product, which shows some structural similarity to vertebrate voltage-gated Ca2+ channels, may thus define a novel family of second-messenger-operated Ca2+ channels generally responsible for the widespread but poorly understood phenomenon of phosphoinositide-mediated Ca2+ entry. The other channel is a non-selective cation channel that requires Ca2+ for activation. As well as being a major charge carrier for the light-induced current, Ca2+ influx via the trp-dependent channels appears to be required for refilling Ca2+ stores sensitive to inositol 1,4,5-trisphosphate and for feedback regulation (light adaptation) of the transduction cascade.
AB - Drosophila photoreceptors are excellent models for studies of the ubiquitous phosphoinositide signalling cascade. Recent studies suggest that light-induced phosphoinositide hydrolysis in Drosophila leads to the activation of two classes of channels. One is selective for Ca2+ and absent in the transient receptor potential mutant trp. The trp gene product, which shows some structural similarity to vertebrate voltage-gated Ca2+ channels, may thus define a novel family of second-messenger-operated Ca2+ channels generally responsible for the widespread but poorly understood phenomenon of phosphoinositide-mediated Ca2+ entry. The other channel is a non-selective cation channel that requires Ca2+ for activation. As well as being a major charge carrier for the light-induced current, Ca2+ influx via the trp-dependent channels appears to be required for refilling Ca2+ stores sensitive to inositol 1,4,5-trisphosphate and for feedback regulation (light adaptation) of the transduction cascade.
UR - http://www.scopus.com/inward/record.url?scp=0027338192&partnerID=8YFLogxK
U2 - 10.1016/0166-2236(93)90095-4
DO - 10.1016/0166-2236(93)90095-4
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 7694408
AN - SCOPUS:0027338192
SN - 0166-2236
VL - 16
SP - 371
EP - 376
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 9
ER -