Novel cbg derivatives can reduce inflammation, pain and obesity

Natalya M. Kogan; Yarden Lavi; Louise M. Topping; Richard O. Williams; Fiona E. McCann; Zhanna Yekhtin; Marc Feldmann; Ruth Gallily; Raphael Mechoulam

doi:10.3390/molecules26185601

Novel cbg derivatives can reduce inflammation, pain and obesity

Natalya M. Kogan^*, Yarden Lavi, Louise M. Topping, Richard O. Williams, Fiona E. McCann, Zhanna Yekhtin, Marc Feldmann, Ruth Gallily, Raphael Mechoulam

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need.

Original language	English
Article number	5601
Journal	Molecules
Volume	26
Issue number	18
DOIs	https://doi.org/10.3390/molecules26185601
State	Published - 15 Sep 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Anti-inflammatory
Cannabigerol
Cannabinoid
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules26185601

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title = "Novel cbg derivatives can reduce inflammation, pain and obesity",

abstract = "Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need.",

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AU - Lavi, Yarden

AU - Topping, Louise M.

AU - Williams, Richard O.

AU - McCann, Fiona E.

AU - Yekhtin, Zhanna

AU - Feldmann, Marc

AU - Gallily, Ruth

AU - Mechoulam, Raphael

PY - 2021/9/15

Y1 - 2021/9/15

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AB - Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need.

KW - Anti-inflammatory

KW - Cannabigerol

KW - Cannabinoid

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Novel cbg derivatives can reduce inflammation, pain and obesity

Abstract

Bibliographical note

Keywords

UN SDGs

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