Novel concepts for improved communication between nerve cells and silicon electronic devices

Roeland Huys; Dries Braeken; Bart Van Meerbergen; Kurt Winters; Wolfgang Eberle; Josine Loo; Diana Tsvetanova; Chang Chen; Simone Severi; S. Yitzchaik; M. Spira; J. Shappir; Geert Callewaert; Gustaaf Borghs; Carmen Bartic

doi:10.1016/j.sse.2007.10.025

Novel concepts for improved communication between nerve cells and silicon electronic devices

Roeland Huys^*, Dries Braeken, Bart Van Meerbergen, Kurt Winters, Wolfgang Eberle, Josine Loo, Diana Tsvetanova, Chang Chen, Simone Severi, S. Yitzchaik, M. Spira, J. Shappir, Geert Callewaert, Gustaaf Borghs, Carmen Bartic

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Hybrid integration of living cells and electronic circuits on a chip requires a high-density matrix of sensors and actuators. This matrix must be processable on top of CMOS devices and must be bio-compatible in order to support living cells. Recent studies have shown that the use of nail structures combined with a phagocytosis-like event of the cell can be exploited to improve the electrical coupling between a cell and a sensor. In this paper, two CMOS-compatible fabrication methods for sub-micron nails will be presented. The biocompatibility and proof-of-concept is demonstrated by the culturing of PC12 neuroblastoma cells. Electrical functionality is shown by simultaneous stimulation and recording of pig cardiomyocyte cells. Biocompatibility aspects for more demanding cortical cell cultures have been addressed in a preliminary assessment.

Original language	English
Pages (from-to)	533-539
Number of pages	7
Journal	Solid-State Electronics
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/j.sse.2007.10.025
State	Published - Apr 2008

Keywords

Biocompatibility
Biosensors
Cardiomyocyte recording
Cytotoxicity
Micro-nails
Neuronal recording
Neurons-on-chip
Neurophysiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.sse.2007.10.025

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Huys, R., Braeken, D., Van Meerbergen, B., Winters, K., Eberle, W., Loo, J., Tsvetanova, D., Chen, C., Severi, S., Yitzchaik, S., Spira, M., Shappir, J., Callewaert, G., Borghs, G., & Bartic, C. (2008). Novel concepts for improved communication between nerve cells and silicon electronic devices. Solid-State Electronics, 52(4), 533-539. https://doi.org/10.1016/j.sse.2007.10.025

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abstract = "Hybrid integration of living cells and electronic circuits on a chip requires a high-density matrix of sensors and actuators. This matrix must be processable on top of CMOS devices and must be bio-compatible in order to support living cells. Recent studies have shown that the use of nail structures combined with a phagocytosis-like event of the cell can be exploited to improve the electrical coupling between a cell and a sensor. In this paper, two CMOS-compatible fabrication methods for sub-micron nails will be presented. The biocompatibility and proof-of-concept is demonstrated by the culturing of PC12 neuroblastoma cells. Electrical functionality is shown by simultaneous stimulation and recording of pig cardiomyocyte cells. Biocompatibility aspects for more demanding cortical cell cultures have been addressed in a preliminary assessment.",

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Huys, R, Braeken, D, Van Meerbergen, B, Winters, K, Eberle, W, Loo, J, Tsvetanova, D, Chen, C, Severi, S, Yitzchaik, S, Spira, M, Shappir, J, Callewaert, G, Borghs, G & Bartic, C 2008, 'Novel concepts for improved communication between nerve cells and silicon electronic devices', Solid-State Electronics, vol. 52, no. 4, pp. 533-539. https://doi.org/10.1016/j.sse.2007.10.025

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AU - Tsvetanova, Diana

AU - Chen, Chang

AU - Severi, Simone

AU - Yitzchaik, S.

AU - Spira, M.

AU - Shappir, J.

AU - Callewaert, Geert

AU - Borghs, Gustaaf

AU - Bartic, Carmen

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Novel concepts for improved communication between nerve cells and silicon electronic devices

Abstract

Keywords

UN SDGs

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