Novel therapeutic strategies against cytomegalovirus infection

B. Ranger-Zisman*, A. Palmon, S. Blagerman, S. Tel-Or, D. Benharroch, M. Pecht, N. Trainin, Y. Burstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Murine CMV (MCMV) presents a model for the study of the role of the immune system in the pathogenesis of human CMV (HCMV) infection. MCMV causes T cell immune impairment in the infected mice, manifested by suppressed responses to T cell mitogens and a profound reduction of Con A induced IL-2 production. Thymic humoral factor (THF-γ2) is an octapeptide which was first isolated from calf thymus, characterized and chemically synthesized. This peptide has been shown to have immunoregulatory effects in various systems. Systemic treatment of MCMV-infected mice with THF-γ2 resulted in the enhancement of protective efficacy of MCMV immune spleen cells and the reconstitution of mitogenic responses and IL-2 secretion.

Original languageAmerican English
Pages (from-to)250-261
Number of pages12
JournalNatural Immunity
Volume14
Issue number5-6
StatePublished - 1995
Externally publishedYes

Keywords

  • Adoptive transfers
  • Immunotherapy
  • Interleukin-2
  • Mitogenic responses
  • Murine cytomegalovirus
  • Thymic humoral factor

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