Abstract
Murine CMV (MCMV) presents a model for the study of the role of the immune system in the pathogenesis of human CMV (HCMV) infection. MCMV causes T cell immune impairment in the infected mice, manifested by suppressed responses to T cell mitogens and a profound reduction of Con A induced IL-2 production. Thymic humoral factor (THF-γ2) is an octapeptide which was first isolated from calf thymus, characterized and chemically synthesized. This peptide has been shown to have immunoregulatory effects in various systems. Systemic treatment of MCMV-infected mice with THF-γ2 resulted in the enhancement of protective efficacy of MCMV immune spleen cells and the reconstitution of mitogenic responses and IL-2 secretion.
| Original language | English |
|---|---|
| Pages (from-to) | 250-261 |
| Number of pages | 12 |
| Journal | Natural Immunity |
| Volume | 14 |
| Issue number | 5-6 |
| State | Published - 1995 |
| Externally published | Yes |
Keywords
- Adoptive transfers
- Immunotherapy
- Interleukin-2
- Mitogenic responses
- Murine cytomegalovirus
- Thymic humoral factor