Nuclear imaging in mechanobiology

Irena L. Ivanovska, Joe Swift, Jerome Irianto, Kyle Spinler, Jae Won Shin, Amnon Buxboim, Dennis E. Discher

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


All of the different cells within an individual share the same genome, whereas epigenetic variations underlie the plasticity in gene expression from the stem cells that differentiate during development, repair, and aging. Beyond differences in covalent and noncovalent modifications of chromatin between different cell types, there are also lineage-relevant variations in the structure proteins of the nuclear envelope called lamins that contribute to chromatin organization and even transcription factor localization. Here we focus on imaging these various molecular factors with the relevant optical microscopy in the context of multiple methods for physically manipulating nuclei.

Original languageAmerican English
Title of host publicationHandbook of Imaging in Biological Mechanics
PublisherCRC Press
Number of pages13
ISBN (Electronic)9781466588141
ISBN (Print)9781466588134
StatePublished - 1 Jan 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 by Taylor & Francis Group, LLC.


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