TY - JOUR
T1 - Nuclear lamins, diseases and aging
AU - Mattout, Anna
AU - Dechat, Thomas
AU - Adam, Stephen A.
AU - Goldman, Robert D.
AU - Gruenbaum, Yosef
PY - 2006/6
Y1 - 2006/6
N2 - Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane. In addition to providing nuclear shape and mechanical stability, they are required for chromatin organization, transcription regulation, DNA replication, nuclear assembly and nuclear positioning. Over the past few years, interest in the lamins has increased because of the identification of at least 12 distinct human diseases associated with mutations in the LMNA gene, which encodes A-type lamins. These diseases, collectively termed laminopathies, affect muscle, adipose, bone, nerve and skin cells and range from muscular dystrophies to accelerated aging.
AB - Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane. In addition to providing nuclear shape and mechanical stability, they are required for chromatin organization, transcription regulation, DNA replication, nuclear assembly and nuclear positioning. Over the past few years, interest in the lamins has increased because of the identification of at least 12 distinct human diseases associated with mutations in the LMNA gene, which encodes A-type lamins. These diseases, collectively termed laminopathies, affect muscle, adipose, bone, nerve and skin cells and range from muscular dystrophies to accelerated aging.
UR - http://www.scopus.com/inward/record.url?scp=33646536969&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2006.03.007
DO - 10.1016/j.ceb.2006.03.007
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 16632339
AN - SCOPUS:33646536969
SN - 0955-0674
VL - 18
SP - 335
EP - 341
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -