Nuclear magnetic resonance spectra of xanthines and thioxanthines

D. Lichtenberg; F. Bergmann; Z. Neiman

doi:10.1039/J39710001939

Nuclear magnetic resonance spectra of xanthines and thioxanthines

D. Lichtenberg
, F. Bergmann^*
, Z. Neiman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The n.m.r. signal of the 8-proton in xanthines is shifted downfield more strongly by introduction of a 2 -than of a 6-thioxo-group. The signals of N-methyl groups are also shifted to lower field, but the effect depends strictly on the distance between the methyl and the thioxo-group. Thus in 2-thioxanthines, the displacement decreases in the following order: 1-methyl = 3-methyl > 7-methyl, and in 6-thioxanthines the sequence is 1-methyl > 7-methyl > 3-methyl > 9-methyl.

Original language	English
Pages (from-to)	1939-1941
Number of pages	3
Journal	Journal of the Chemical Society C: Organic Chemistry
DOIs	https://doi.org/10.1039/J39710001939
State	Published - 1971

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title = "Nuclear magnetic resonance spectra of xanthines and thioxanthines",

abstract = "The n.m.r. signal of the 8-proton in xanthines is shifted downfield more strongly by introduction of a 2 -than of a 6-thioxo-group. The signals of N-methyl groups are also shifted to lower field, but the effect depends strictly on the distance between the methyl and the thioxo-group. Thus in 2-thioxanthines, the displacement decreases in the following order: 1-methyl = 3-methyl > 7-methyl, and in 6-thioxanthines the sequence is 1-methyl > 7-methyl > 3-methyl > 9-methyl.",

author = "D. Lichtenberg and F. Bergmann and Z. Neiman",

year = "1971",

doi = "10.1039/J39710001939",

language = "אנגלית",

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journal = "Journal of the Chemical Society C: Organic Chemistry",

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T1 - Nuclear magnetic resonance spectra of xanthines and thioxanthines

AU - Lichtenberg, D.

AU - Bergmann, F.

AU - Neiman, Z.

PY - 1971

Y1 - 1971

N2 - The n.m.r. signal of the 8-proton in xanthines is shifted downfield more strongly by introduction of a 2 -than of a 6-thioxo-group. The signals of N-methyl groups are also shifted to lower field, but the effect depends strictly on the distance between the methyl and the thioxo-group. Thus in 2-thioxanthines, the displacement decreases in the following order: 1-methyl = 3-methyl > 7-methyl, and in 6-thioxanthines the sequence is 1-methyl > 7-methyl > 3-methyl > 9-methyl.

AB - The n.m.r. signal of the 8-proton in xanthines is shifted downfield more strongly by introduction of a 2 -than of a 6-thioxo-group. The signals of N-methyl groups are also shifted to lower field, but the effect depends strictly on the distance between the methyl and the thioxo-group. Thus in 2-thioxanthines, the displacement decreases in the following order: 1-methyl = 3-methyl > 7-methyl, and in 6-thioxanthines the sequence is 1-methyl > 7-methyl > 3-methyl > 9-methyl.

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DO - 10.1039/J39710001939

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AN - SCOPUS:37049124326

SN - 0022-4952

SP - 1939

EP - 1941

JO - Journal of the Chemical Society C: Organic Chemistry

JF - Journal of the Chemical Society C: Organic Chemistry

ER -

Nuclear magnetic resonance spectra of xanthines and thioxanthines

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