Nucleic acid-functionalized Pt nanoparticles: Catalytic labels for the amplified electrochemical detection of biomolecules

Ronen Polsky, Ron Gill, Lubov Kaganovsky, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

460 Scopus citations

Abstract

Nucleic acid-functionalized Pt nanoparticles (Pt-NPs) act as catalytic labels for the amplified electrochemical detection of DNA hybridization and aptamer/protein recognition. Hybridization of the nucleic acid-modified Pt-NPs with a sensing nucleic acid/analyte DNA complex associated with an electrode enables the amperometric, amplified, detection of the DNA by the Pt NP electrocatalyzed reduction of H2O2 (sensitivity limit, 1 × 10-11 M). Similarly, the association of aptamer- functionalized Pt-NPs to a thrombin aptamer/thrombin complex associated with an electrode allowed the amplified, electrocatalytic detection of thrombin with a sensitivity limit corresponding to 1 × 10-9 M.

Original languageEnglish
Pages (from-to)2268-2271
Number of pages4
JournalAnalytical Chemistry
Volume78
Issue number7
DOIs
StatePublished - 1 Apr 2006

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