Nylon-3 polymers with selective antifungal activity

Runhui Liu, Xinyu Chen, Zvi Hayouka, Saswata Chakraborty, Shaun P. Falk, Bernard Weisblum, Kristyn S. Masters*, Samuel H. Gellman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

Host-defense peptides inhibit bacterial growth but show little toxicity toward mammalian cells. A variety of synthetic polymers have been reported to mimic this antibacterial selectivity; however, achieving comparable selectivity for fungi is more difficult because these pathogens are eukaryotes. Here we report nylon-3 polymers based on a novel subunit that display potent antifungal activity (MIC = 3.1 μg/mL for Candida albicans) and favorable selectivity (IC10 > 400 μg/mL for 3T3 fibroblast toxicity; HC10 > 400 μg/mL for hemolysis).

Original languageAmerican English
Pages (from-to)5270-5273
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number14
DOIs
StatePublished - 10 Apr 2013
Externally publishedYes

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