Nylon-3 polymers with selective antifungal activity

Runhui Liu; Xinyu Chen; Zvi Hayouka; Saswata Chakraborty; Shaun P. Falk; Bernard Weisblum; Kristyn S. Masters; Samuel H. Gellman

doi:10.1021/ja4006404

Nylon-3 polymers with selective antifungal activity

Runhui Liu, Xinyu Chen, Zvi Hayouka, Saswata Chakraborty, Shaun P. Falk, Bernard Weisblum, Kristyn S. Masters^*, Samuel H. Gellman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Host-defense peptides inhibit bacterial growth but show little toxicity toward mammalian cells. A variety of synthetic polymers have been reported to mimic this antibacterial selectivity; however, achieving comparable selectivity for fungi is more difficult because these pathogens are eukaryotes. Here we report nylon-3 polymers based on a novel subunit that display potent antifungal activity (MIC = 3.1 μg/mL for Candida albicans) and favorable selectivity (IC₁₀ > 400 μg/mL for 3T3 fibroblast toxicity; HC₁₀ > 400 μg/mL for hemolysis).

Original language	English
Pages (from-to)	5270-5273
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	14
DOIs	https://doi.org/10.1021/ja4006404
State	Published - 10 Apr 2013
Externally published	Yes

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10.1021/ja4006404

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title = "Nylon-3 polymers with selective antifungal activity",

abstract = "Host-defense peptides inhibit bacterial growth but show little toxicity toward mammalian cells. A variety of synthetic polymers have been reported to mimic this antibacterial selectivity; however, achieving comparable selectivity for fungi is more difficult because these pathogens are eukaryotes. Here we report nylon-3 polymers based on a novel subunit that display potent antifungal activity (MIC = 3.1 μg/mL for Candida albicans) and favorable selectivity (IC10 > 400 μg/mL for 3T3 fibroblast toxicity; HC10 > 400 μg/mL for hemolysis).",

author = "Runhui Liu and Xinyu Chen and Zvi Hayouka and Saswata Chakraborty and Falk, {Shaun P.} and Bernard Weisblum and Masters, {Kristyn S.} and Gellman, {Samuel H.}",

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AU - Liu, Runhui

AU - Chen, Xinyu

AU - Hayouka, Zvi

AU - Chakraborty, Saswata

AU - Falk, Shaun P.

AU - Weisblum, Bernard

AU - Masters, Kristyn S.

AU - Gellman, Samuel H.

PY - 2013/4/10

Y1 - 2013/4/10

N2 - Host-defense peptides inhibit bacterial growth but show little toxicity toward mammalian cells. A variety of synthetic polymers have been reported to mimic this antibacterial selectivity; however, achieving comparable selectivity for fungi is more difficult because these pathogens are eukaryotes. Here we report nylon-3 polymers based on a novel subunit that display potent antifungal activity (MIC = 3.1 μg/mL for Candida albicans) and favorable selectivity (IC10 > 400 μg/mL for 3T3 fibroblast toxicity; HC10 > 400 μg/mL for hemolysis).

AB - Host-defense peptides inhibit bacterial growth but show little toxicity toward mammalian cells. A variety of synthetic polymers have been reported to mimic this antibacterial selectivity; however, achieving comparable selectivity for fungi is more difficult because these pathogens are eukaryotes. Here we report nylon-3 polymers based on a novel subunit that display potent antifungal activity (MIC = 3.1 μg/mL for Candida albicans) and favorable selectivity (IC10 > 400 μg/mL for 3T3 fibroblast toxicity; HC10 > 400 μg/mL for hemolysis).

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 14

ER -

Nylon-3 polymers with selective antifungal activity

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