TY - JOUR
T1 - Obesity and blood pressure in 17-Year-old offspring of mothers with gestational diabetes
T2 - Insights from the jerusalem perinatal study
AU - Avgil Tsadok, Meytal
AU - Friedlander, Yechiel
AU - Paltiel, Ora
AU - Manor, Orly
AU - Meiner, Vardiella
AU - Hochner, Hagit
AU - Sagy, Yael
AU - Sharon, Nir
AU - Yazdgerdi, Shoshanah
AU - Siscovick, David
AU - Elchalal, Uriel
PY - 2011
Y1 - 2011
N2 - Objective. Gestational diabetes mellitus (GDM) influences fetal development and offspring's metabolic risk. We evaluated this association in 17-year-old offspring adjusting for birth weight (BW) and prepregnancy maternal BMI (mBMI). Study Design. The JPS birth cohort contains extensive data on 92,408 births from 1964 to 1976. Offspring's BMI and blood pressure (BP) were obtained from military records. For a subcohort born between 1974 and 1976, prepregnancy mBMI was available. Offspring were classified as born to mothers with GDM (n = 293) or born to mothers without recorded GDM (n = 59,499). Results. GDM offspring had higher mean BMI and systolic and diastolic BP compared to no-recorded-GDM offspring. After adjusting for BW, GDM remained significantly associated with offspring BMI and diastolic BP (β = 1.169 and 1.520, resp.). In the subcohort, when prepregnancy mBMI was entered to the models, it markedly attenuated the associations with GDM. Conclusions. Maternal characteristics have long-term effects on cardiometabolic outcomes of their offspring aged 17 years.
AB - Objective. Gestational diabetes mellitus (GDM) influences fetal development and offspring's metabolic risk. We evaluated this association in 17-year-old offspring adjusting for birth weight (BW) and prepregnancy maternal BMI (mBMI). Study Design. The JPS birth cohort contains extensive data on 92,408 births from 1964 to 1976. Offspring's BMI and blood pressure (BP) were obtained from military records. For a subcohort born between 1974 and 1976, prepregnancy mBMI was available. Offspring were classified as born to mothers with GDM (n = 293) or born to mothers without recorded GDM (n = 59,499). Results. GDM offspring had higher mean BMI and systolic and diastolic BP compared to no-recorded-GDM offspring. After adjusting for BW, GDM remained significantly associated with offspring BMI and diastolic BP (β = 1.169 and 1.520, resp.). In the subcohort, when prepregnancy mBMI was entered to the models, it markedly attenuated the associations with GDM. Conclusions. Maternal characteristics have long-term effects on cardiometabolic outcomes of their offspring aged 17 years.
UR - http://www.scopus.com/inward/record.url?scp=80052754105&partnerID=8YFLogxK
U2 - 10.1155/2011/906154
DO - 10.1155/2011/906154
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C2 - 21804818
AN - SCOPUS:80052754105
SN - 1687-5214
VL - 2011
JO - Experimental Diabetes Research
JF - Experimental Diabetes Research
M1 - 906154
ER -
