Obesity and chronodisruption: An imbalance between energy intake and expenditure

Oren Froy*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Obesity has become a serious public health problem and a major risk factor for the development of illnesses, such as insulin resistance and hypertension. Attempts to understand the causes of obesity and develop new therapeutic strategies have mostly focused on caloric intake and energy expenditure. Recent studies have shown that the circadian clock controls energy homeostasis by regulating circadian expression and/or activity of enzymes, hormones, and transport systems involved in metabolism. Moreover, disruption of circadian rhythms leads to obesity and metabolic disorders. Therefore, it is plausible that resetting of the circadian clock can be used as a new approach to attenuate obesity. Feeding regimens, such as restricted feeding (RF), calorie restriction (CR) and intermittent fasting (IF), provide a time cue and reset the circadian clock and lead to better health. In contrast, high-fat (HF) diet leads to disrupted circadian expression of metabolic factors and obesity. This chapter will focus on chronodisruption and feeding regimens with implications for obesity.

Original languageAmerican English
Title of host publicationChronobiology and Obesity
PublisherSpringer New York
Number of pages14
ISBN (Electronic)9781461450825
ISBN (Print)1461450810, 9781461450818
StatePublished - 1 Nov 2013

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2013. All rights are reserved.


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