Oct4 shuffles Sox partners to direct cell fate

Abed Alfatah Mansour; Jacob H. Hanna

doi:10.1038/emboj.2013.48

Oct4 shuffles Sox partners to direct cell fate

Abed Alfatah Mansour, Jacob H. Hanna^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The transcription factor Oct4 plays a crucial role in the maintenance of the embryonic pluripotent state, but can also regulate early lineage commitment. In this issue of The EMBO Journal, Aksoy et al (2013) lend critical mechanistic insights into the ability of Oct4 to regulate and specify the primitive endodermal lineage. These regulatory actions are governed by alternative direct partnering of Oct4 with Sox17, instead of Sox2, that leads to global reprogramming of enhancer occupancy by Oct4 during primitive endoderm differentiation.

Original language	English
Pages (from-to)	917-919
Number of pages	3
Journal	EMBO Journal
Volume	32
Issue number	7
DOIs	https://doi.org/10.1038/emboj.2013.48
State	Published - 3 Apr 2013
Externally published	Yes

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10.1038/emboj.2013.48

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Oct4 shuffles Sox partners to direct cell fate

Abstract

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