Odor processing by adult-born neurons

Yoav Livneh, Yoav Adam, Adi Mizrahi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

The adult mammalian brain is continuously supplied with adult-born neurons in the olfactory bulb (OB) and hippocampus, where they are thought to be important for circuit coding and plasticity. However, direct evidence for the actual involvement of these neurons in neural processing is still lacking. We recorded the spiking activity of adult-born periglomerular neurons in the mouse OB in vivo using two-photon-targeted patch recordings. We show that odor responsiveness reaches a peak during neuronal development and then recedes at maturity. Sensory enrichment during development enhances the selectivity of adult-born neurons after maturation, without affecting neighboring resident neurons. Thus, in the OB circuit, adult-born neurons functionally integrate into the circuit, where they acquire distinct response profiles in an experience-dependent manner. The constant flow of these sensitive neurons into the circuit provides it with a mechanism of long-term plasticity, wherein new neurons mature to process odor information based on past demands.

Original languageAmerican English
Pages (from-to)1097-1110
Number of pages14
JournalNeuron
Volume81
Issue number5
DOIs
StatePublished - 5 Mar 2014

Bibliographical note

Funding Information:
We thank the members of the Mizrahi Lab and D. Nachmani for discussions and critical reading of the manuscript. We thank N. Book, A. Vinograd, and G. Tasaka for technical assistance. Y.L. is supported by the Adams Fellowship Program of the Israel Academy of Sciences and Humanities. This work was supported by the European Research Council Grant (number 203994) and Israeli Science Foundation grant (number 1284/10) to A.M.

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