TY - JOUR
T1 - Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection
AU - COMMIT-KZN TEAM
AU - Khan, Khadija
AU - Karim, Farina
AU - Ganga, Yashica
AU - Bernstein, Mallory
AU - Jule, Zesuliwe
AU - Reedoy, Kajal
AU - Cele, Sandile
AU - Lustig, Gila
AU - Amoako, Daniel
AU - Wolter, Nicole
AU - Samsunder, Natasha
AU - Sivro, Aida
AU - San, James Emmanuel
AU - Giandhari, Jennifer
AU - Tegally, Houriiyah
AU - Pillay, Sureshnee
AU - Naidoo, Yeshnee
AU - Mazibuko, Matilda
AU - Miya, Yoliswa
AU - Ngcobo, Nokuthula
AU - Manickchund, Nithendra
AU - Magula, Nombulelo
AU - Karim, Quarraisha Abdool
AU - von Gottberg, Anne
AU - Abdool Karim, Salim S.
AU - Hanekom, Willem
AU - Gosnell, Bernadett I.
AU - Khoza, Thandeka
AU - Smit, Theresa
AU - Wong, Emily
AU - Lessells, Richard J.
AU - de Oliveira, Tulio
AU - Moosa, Mahomed Yunus S.
AU - Sigal, Alex
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.
AB - SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.
UR - https://www.scopus.com/pages/publications/85135803088
U2 - 10.1038/s41467-022-32396-9
DO - 10.1038/s41467-022-32396-9
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C2 - 35948557
AN - SCOPUS:85135803088
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 4686
ER -
