TY - JOUR
T1 - Omiderm, a new synthetic wound covering
T2 - Physical properties and drug permeability studies
AU - Behar, D.
AU - Juszynski, M.
AU - Ben Hur, N.
AU - Golan, J.
AU - Eldad, A.
AU - Tuchman, Y.
AU - Sterenberg, N.
AU - Rudensky, B.
PY - 1986
Y1 - 1986
N2 - Omiderm (Omikron Scientific Ltd., Rehovot, Israel), a new synthetic wound covering based on hydrophilized polyurethane, was found to be highly permeable to water. Values in the region of 5000 g/m2 24 h were found for the water permeability of Omiderm in comparison to 1400 and 500 g/m2 24 h for Biobrane (Hall, Woodroof Inc., Santa Ana, CA) and Op site (Smith and Nephew Ltd.), respectively. Permeabilities of antibacterial agents through Omiderm were found to be two to three orders of magnitude greater than those through Biobrane. The in vitro effectiveness of various antibacterial agents in lowering bacterial growth of different bacterial strains when applied to seeded agar plates through Omiderm membrane was investigated. NBH ointment (1% Neomycin, 1% Bacitracin, and 0.5% Hydrocortisone) was found to be the most effective material in inhibiting bacterial growth, except for Pseudomonas aeruginosa where silver sulfadiazine was superior. In in vivo experiments bacterial counts of infected wounds covered with Omiderm and topically treated with NBH were lowered to less than 103 organism/g tissue after one day of treatment.
AB - Omiderm (Omikron Scientific Ltd., Rehovot, Israel), a new synthetic wound covering based on hydrophilized polyurethane, was found to be highly permeable to water. Values in the region of 5000 g/m2 24 h were found for the water permeability of Omiderm in comparison to 1400 and 500 g/m2 24 h for Biobrane (Hall, Woodroof Inc., Santa Ana, CA) and Op site (Smith and Nephew Ltd.), respectively. Permeabilities of antibacterial agents through Omiderm were found to be two to three orders of magnitude greater than those through Biobrane. The in vitro effectiveness of various antibacterial agents in lowering bacterial growth of different bacterial strains when applied to seeded agar plates through Omiderm membrane was investigated. NBH ointment (1% Neomycin, 1% Bacitracin, and 0.5% Hydrocortisone) was found to be the most effective material in inhibiting bacterial growth, except for Pseudomonas aeruginosa where silver sulfadiazine was superior. In in vivo experiments bacterial counts of infected wounds covered with Omiderm and topically treated with NBH were lowered to less than 103 organism/g tissue after one day of treatment.
UR - http://www.scopus.com/inward/record.url?scp=0022757729&partnerID=8YFLogxK
U2 - 10.1002/jbm.820200607
DO - 10.1002/jbm.820200607
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C2 - 3722212
AN - SCOPUS:0022757729
SN - 0021-9304
VL - 20
SP - 731
EP - 738
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 6
ER -