Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems

Roi Rutenberg, Daria Galaktionova, Gilad Golden, Yael Cohen, Yael Levi-Kalisman, Guy Cohen, Petr Král, Elena Poverenov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics.

Original languageAmerican English
Pages (from-to)36711-36720
Number of pages10
JournalACS applied materials & interfaces
Volume10
Issue number43
DOIs
StatePublished - 31 Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

Keywords

  • atomistic molecular dynamics simulations
  • cross-phase delivery
  • omniphilic
  • pH responsive release
  • polysaccharide
  • self-assembly

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