Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems

Roi Rutenberg; Daria Galaktionova; Gilad Golden; Yael Cohen; Yael Levi-Kalisman; Guy Cohen; Petr Král; Elena Poverenov

doi:10.1021/acsami.8b12855

Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems

Roi Rutenberg, Daria Galaktionova, Gilad Golden, Yael Cohen, Yael Levi-Kalisman, Guy Cohen, Petr Král, Elena Poverenov^*

^*Corresponding author for this work

Unit for Nano Characterization (UNC)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics.

Original language	American English
Pages (from-to)	36711-36720
Number of pages	10
Journal	ACS applied materials & interfaces
Volume	10
Issue number	43
DOIs	https://doi.org/10.1021/acsami.8b12855
State	Published - 31 Oct 2018

Bibliographical note

Funding Information:
This research was supported by the Chief Scientist of the Israeli Ministry of Agriculture, grant no. 421-0383-18. Contribution from the Agricultural Research Organization, The Volcani Center, no 815/18. The study was also partially supported by the Ministry of Science and Technology, Israel. P.K. was supported by the NSF-DMR grant 1506886. The authors would like to thank Eduard Belausov for CLSM imaging and analysis.

Funding Information:
This research was supported by the Chief Scientist of the Israeli Ministry of Agriculture, grant no. 421-0383-18. Contribution from the Agricultural Research Organization The Volcani Center, no 815/18. The study was also partially supported by the Ministry of Science and Technology, Israel. P.K. was supported by the NSF-DMR grant 1506886. The authors would like to thank Eduard Belausov for CLSM imaging and analysis.

Publisher Copyright:
© 2018 American Chemical Society.

Keywords

atomistic molecular dynamics simulations
cross-phase delivery
omniphilic
pH responsive release
polysaccharide
self-assembly

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10.1021/acsami.8b12855

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abstract = "Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics.",

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author = "Roi Rutenberg and Daria Galaktionova and Gilad Golden and Yael Cohen and Yael Levi-Kalisman and Guy Cohen and Petr Kr{\'a}l and Elena Poverenov",

note = "Funding Information: This research was supported by the Chief Scientist of the Israeli Ministry of Agriculture, grant no. 421-0383-18. Contribution from the Agricultural Research Organization, The Volcani Center, no 815/18. The study was also partially supported by the Ministry of Science and Technology, Israel. P.K. was supported by the NSF-DMR grant 1506886. The authors would like to thank Eduard Belausov for CLSM imaging and analysis. Funding Information: This research was supported by the Chief Scientist of the Israeli Ministry of Agriculture, grant no. 421-0383-18. Contribution from the Agricultural Research Organization The Volcani Center, no 815/18. The study was also partially supported by the Ministry of Science and Technology, Israel. P.K. was supported by the NSF-DMR grant 1506886. The authors would like to thank Eduard Belausov for CLSM imaging and analysis. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

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Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems

Abstract

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Keywords

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