Abstract
Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics.
Original language | American English |
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Pages (from-to) | 36711-36720 |
Number of pages | 10 |
Journal | ACS applied materials & interfaces |
Volume | 10 |
Issue number | 43 |
DOIs | |
State | Published - 31 Oct 2018 |
Bibliographical note
Funding Information:This research was supported by the Chief Scientist of the Israeli Ministry of Agriculture, grant no. 421-0383-18. Contribution from the Agricultural Research Organization, The Volcani Center, no 815/18. The study was also partially supported by the Ministry of Science and Technology, Israel. P.K. was supported by the NSF-DMR grant 1506886. The authors would like to thank Eduard Belausov for CLSM imaging and analysis.
Funding Information:
This research was supported by the Chief Scientist of the Israeli Ministry of Agriculture, grant no. 421-0383-18. Contribution from the Agricultural Research Organization The Volcani Center, no 815/18. The study was also partially supported by the Ministry of Science and Technology, Israel. P.K. was supported by the NSF-DMR grant 1506886. The authors would like to thank Eduard Belausov for CLSM imaging and analysis.
Publisher Copyright:
© 2018 American Chemical Society.
Keywords
- atomistic molecular dynamics simulations
- cross-phase delivery
- omniphilic
- pH responsive release
- polysaccharide
- self-assembly