On the driving forces for protein-protein association

Arieh Ben-Naim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

We analyze all the contributions to the standard free energy of association between two proteins. We find that the solvent-induced interactions between two (or more) hydrophilic groups can turn a highly unfavorable process of association into a highly favorable one. We therefore argue that in contrast to the generally accepted view, it is the hydrophilic rather than the hydrophobic effect that is dominant in biochemical processes such as protein-protein association, protein folding, and protein binding to DNA.

Original languageEnglish
Article number024901
JournalJournal of Chemical Physics
Volume125
Issue number2
DOIs
StatePublished - 2006

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