TY - JOUR

T1 - On the establishment of a mutant

AU - Baker, Jeremy

AU - Chigansky, Pavel

AU - Jagers, Peter

AU - Klebaner, Fima C.

N1 - Publisher Copyright:
© 2020, The Author(s).

PY - 2020/5/1

Y1 - 2020/5/1

N2 - How long does it take for an initially advantageous mutant to establish itself in a resident population, and what does the population composition look like then? We approach these questions in the framework of the so called Bare Bones evolution model (Klebaner et al. in J Biol Dyn 5(2):147–162, 2011. https://doi.org/10.1080/17513758.2010.506041) that provides a simplified approach to the adaptive population dynamics of binary splitting cells. As the mutant population grows, cell division becomes less probable, and it may in fact turn less likely than that of residents. Our analysis rests on the assumption of the process starting from resident populations, with sizes proportional to a large carrying capacity K. Actually, we assume carrying capacities to be a1K and a2K for the resident and the mutant populations, respectively, and study the dynamics for K→ ∞. We find conditions for the mutant to be successful in establishing itself alongside the resident. The time it takes turns out to be proportional to log K. We introduce the time of establishment through the asymptotic behaviour of the stochastic nonlinear dynamics describing the evolution, and show that it is indeed 1ρlogK, where ρ is twice the probability of successful division of the mutant at its appearance. Looking at the composition of the population, at times 1ρlogK+n,n∈Z+, we find that the densities (i.e. sizes relative to carrying capacities) of both populations follow closely the corresponding two dimensional nonlinear deterministic dynamics that starts at a random point. We characterise this random initial condition in terms of the scaling limit of the corresponding dynamics, and the limit of the properly scaled initial binary splitting process of the mutant. The deterministic approximation with random initial condition is in fact valid asymptotically at all times 1ρlogK+n with n∈ Z.

AB - How long does it take for an initially advantageous mutant to establish itself in a resident population, and what does the population composition look like then? We approach these questions in the framework of the so called Bare Bones evolution model (Klebaner et al. in J Biol Dyn 5(2):147–162, 2011. https://doi.org/10.1080/17513758.2010.506041) that provides a simplified approach to the adaptive population dynamics of binary splitting cells. As the mutant population grows, cell division becomes less probable, and it may in fact turn less likely than that of residents. Our analysis rests on the assumption of the process starting from resident populations, with sizes proportional to a large carrying capacity K. Actually, we assume carrying capacities to be a1K and a2K for the resident and the mutant populations, respectively, and study the dynamics for K→ ∞. We find conditions for the mutant to be successful in establishing itself alongside the resident. The time it takes turns out to be proportional to log K. We introduce the time of establishment through the asymptotic behaviour of the stochastic nonlinear dynamics describing the evolution, and show that it is indeed 1ρlogK, where ρ is twice the probability of successful division of the mutant at its appearance. Looking at the composition of the population, at times 1ρlogK+n,n∈Z+, we find that the densities (i.e. sizes relative to carrying capacities) of both populations follow closely the corresponding two dimensional nonlinear deterministic dynamics that starts at a random point. We characterise this random initial condition in terms of the scaling limit of the corresponding dynamics, and the limit of the properly scaled initial binary splitting process of the mutant. The deterministic approximation with random initial condition is in fact valid asymptotically at all times 1ρlogK+n with n∈ Z.

KW - Evolution models

KW - Limit theorems

KW - Stochastic dynamics

UR - http://www.scopus.com/inward/record.url?scp=85080058570&partnerID=8YFLogxK

U2 - 10.1007/s00285-020-01478-x

DO - 10.1007/s00285-020-01478-x

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C2 - 32103329

AN - SCOPUS:85080058570

SN - 0303-6812

VL - 80

SP - 1733

EP - 1757

JO - Journal of Mathematical Biology

JF - Journal of Mathematical Biology

IS - 6

ER -