TY - JOUR
T1 - On the mechanism of energy transduction in myosin subfragment 1
AU - Botts, J.
AU - Takashi, R.
AU - Torgerson, P.
AU - Hozumi, T.
AU - Muhlrad, A.
AU - Mornet, D.
AU - Morales, M. F.
PY - 1984
Y1 - 1984
N2 - It is proposed that the myosin subfragment 1 moiety of the muscle contractile apparatus is a self-contained 'engine' whose operational plan is based on the interactive nature of ATP (or degradation intermediate) binding and actin binding, made possible by an intersite communication system. It is suggested that the spatial information required for examining this engine can, at least provisionally, be derived from fluorescence resonance energy transfer measurements interpreted by the Forster equation and that the existence of an intersite communication system can be deduced from piecewise detection of interacting pairs of points.
AB - It is proposed that the myosin subfragment 1 moiety of the muscle contractile apparatus is a self-contained 'engine' whose operational plan is based on the interactive nature of ATP (or degradation intermediate) binding and actin binding, made possible by an intersite communication system. It is suggested that the spatial information required for examining this engine can, at least provisionally, be derived from fluorescence resonance energy transfer measurements interpreted by the Forster equation and that the existence of an intersite communication system can be deduced from piecewise detection of interacting pairs of points.
UR - http://www.scopus.com/inward/record.url?scp=0011745773&partnerID=8YFLogxK
U2 - 10.1073/pnas.81.7.2060
DO - 10.1073/pnas.81.7.2060
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AN - SCOPUS:0011745773
SN - 0027-8424
VL - 81
SP - 2060
EP - 2064
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 7 I
ER -