TY - JOUR
T1 - On the quantal hypothesis of neurotransmitter release
T2 - an explanation for the calcium dependence of the binomial parameters
AU - Lustig, Cornel
AU - Parnas, Hanna
AU - Segel, Lee A.
PY - 1986/5/21
Y1 - 1986/5/21
N2 - Results for quantal neurotransmitter release can be explained by assuming a binomial distribution with a population of N elements each with a probability p to release a quantum in a given trial. The binomial parameter N was unexpectedly observed to depend on external calcium concentration and (to a lesser extent) on the frequency of stimulation. This observation is explained here by the hypothesis that the release population is not homogeneous. It is shown that the same hypothesis can also account for other experimental findings. A possible cause for this inhomogeneity is suggested.
AB - Results for quantal neurotransmitter release can be explained by assuming a binomial distribution with a population of N elements each with a probability p to release a quantum in a given trial. The binomial parameter N was unexpectedly observed to depend on external calcium concentration and (to a lesser extent) on the frequency of stimulation. This observation is explained here by the hypothesis that the release population is not homogeneous. It is shown that the same hypothesis can also account for other experimental findings. A possible cause for this inhomogeneity is suggested.
UR - http://www.scopus.com/inward/record.url?scp=0023054477&partnerID=8YFLogxK
U2 - 10.1016/S0022-5193(86)80174-6
DO - 10.1016/S0022-5193(86)80174-6
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C2 - 2878119
AN - SCOPUS:0023054477
SN - 0022-5193
VL - 120
SP - 205
EP - 213
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 2
ER -