On the Suitability of Porcine Labial Mucosa as a Model for Buccal Mucosal Drug Delivery Research

Constantin Itin; Abraham J. Domb; Amnon Hoffman

doi:10.1016/j.xphs.2021.01.007

On the Suitability of Porcine Labial Mucosa as a Model for Buccal Mucosal Drug Delivery Research

Constantin Itin, Abraham J. Domb, Amnon Hoffman^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Contrary to human, porcine mucosa of the inner side of the lip is parakeratinized. Thus, although desirable due to its large surface area, it does not closely resemble human buccal mucosa to be considered a suitable model for systemic drug delivery research. Nevertheless, it can be utilized for comparative screening of topical or systemic delivery of bioactive agents, mostly lipophilic such as cannabinoids.

Original language	English
Pages (from-to)	1863-1864
Number of pages	2
Journal	Journal of Pharmaceutical Sciences
Volume	110
Issue number	4
DOIs	https://doi.org/10.1016/j.xphs.2021.01.007
State	Published - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 American Pharmacists Association®

Keywords

Buccal
Buccal delivery
Cannabinoid
Controlled delivery
Drug delivery
Mucosal delivery
Pharmacokinetics
Transmucosal delivery

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10.1016/j.xphs.2021.01.007

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abstract = "Contrary to human, porcine mucosa of the inner side of the lip is parakeratinized. Thus, although desirable due to its large surface area, it does not closely resemble human buccal mucosa to be considered a suitable model for systemic drug delivery research. Nevertheless, it can be utilized for comparative screening of topical or systemic delivery of bioactive agents, mostly lipophilic such as cannabinoids.",

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AU - Domb, Abraham J.

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AB - Contrary to human, porcine mucosa of the inner side of the lip is parakeratinized. Thus, although desirable due to its large surface area, it does not closely resemble human buccal mucosa to be considered a suitable model for systemic drug delivery research. Nevertheless, it can be utilized for comparative screening of topical or systemic delivery of bioactive agents, mostly lipophilic such as cannabinoids.

KW - Buccal

KW - Buccal delivery

KW - Cannabinoid

KW - Controlled delivery

KW - Drug delivery

KW - Mucosal delivery

KW - Pharmacokinetics

KW - Transmucosal delivery

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ER -

On the Suitability of Porcine Labial Mucosa as a Model for Buccal Mucosal Drug Delivery Research

Abstract

Bibliographical note

Keywords

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