Oncofetal splice-pattern of the human H19 gene

Imad Matouk*, Basim Ayesh, Tamar Schneider, Suhail Ayesh, Patricia Ohana, Nathan De-Groot, Abraham Hochberg, Eithan Galun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

H19 is an imprinted gene that demonstrates maternal monoallelic expression in fetal tissues and in some cancers, and very likely does not code for a protein. H19 is involved in the regulation of cell proliferation, embryonic growth, and differentiation through upstream and downstream cis elements that influence the expression of IGF2, a closely physically linked gene, and also through its RNA involved in metastasis and angiogenic processes. We report the identification of an alternatively spliced variant of H19 RNA that lacks part of exon 1. This variant was detected in human embryonic and placental tissues, but not in bladder or hepatocellular carcinomas. A very low level of this variant was also detected in colon carcinoma. The observed pattern of expression suggests that this splice variant is a developmentally regulated H19 gene transcript.

Original languageAmerican English
Pages (from-to)916-919
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume318
Issue number4
DOIs
StatePublished - 11 Jun 2004
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the Horwitz Foundation—The Center for Complexity, the Israeli Ministry of Science, and the Blum Foundation.

Keywords

  • Bladder, colon, and hepatocellular carcinomas
  • Developmentally regulated
  • Embryonic and placental tissues
  • Human H19 gene
  • Splicing
  • Variant

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