Abstract
H19 is an imprinted gene that demonstrates maternal monoallelic expression in fetal tissues and in some cancers, and very likely does not code for a protein. H19 is involved in the regulation of cell proliferation, embryonic growth, and differentiation through upstream and downstream cis elements that influence the expression of IGF2, a closely physically linked gene, and also through its RNA involved in metastasis and angiogenic processes. We report the identification of an alternatively spliced variant of H19 RNA that lacks part of exon 1. This variant was detected in human embryonic and placental tissues, but not in bladder or hepatocellular carcinomas. A very low level of this variant was also detected in colon carcinoma. The observed pattern of expression suggests that this splice variant is a developmentally regulated H19 gene transcript.
Original language | English |
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Pages (from-to) | 916-919 |
Number of pages | 4 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 318 |
Issue number | 4 |
DOIs | |
State | Published - 11 Jun 2004 |
Externally published | Yes |
Bibliographical note
Funding Information:This study was supported by the Horwitz Foundation—The Center for Complexity, the Israeli Ministry of Science, and the Blum Foundation.
Keywords
- Bladder, colon, and hepatocellular carcinomas
- Developmentally regulated
- Embryonic and placental tissues
- Human H19 gene
- Splicing
- Variant