Oncornavirus like particles released from arginine deprived human lymphoblastoid cell lines

M. Kotler, H. Balabanova, E. Weinberg, A. Friedmann, Y. Becker

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Type C RNA tumor virus particles were released from three different human lymphoblastoid cell lines after incubation in arginine deficient medium. The released virus like particles were characterized by their ability to band in sucrose gradients at a density of 1.16-1.18 g/ml; by the presence of an RNA directed DNA polymerase activity resembling that of the oncornaviruses; and by isolation of cores that band at a density of 1.26-1.27 g/ml in sucrose gradients. Examination of the arginine human lymphoblastoid cell strain P 3HR 1 by electron microscopy revealed the presence of C type particles in the intracellular spaces.

Original languageEnglish
Pages (from-to)4592-4596
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume72
Issue number11
DOIs
StatePublished - 1975

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