Abstract
Type C RNA tumor virus particles were released from three different human lymphoblastoid cell lines after incubation in arginine deficient medium. The released virus like particles were characterized by their ability to band in sucrose gradients at a density of 1.16-1.18 g/ml; by the presence of an RNA directed DNA polymerase activity resembling that of the oncornaviruses; and by isolation of cores that band at a density of 1.26-1.27 g/ml in sucrose gradients. Examination of the arginine human lymphoblastoid cell strain P 3HR 1 by electron microscopy revealed the presence of C type particles in the intracellular spaces.
Original language | English |
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Pages (from-to) | 4592-4596 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 72 |
Issue number | 11 |
DOIs | |
State | Published - 1975 |