One year double blind study of high vs low frequency subcallosal cingulate stimulation for depression

Renana Eitan*, Denys Fontaine, Michel Benoît, Caroline Giordana, Nelly Darmon, Zvi Israel, Eduard Linesky, David Arkadir, Shiri Ben-Naim, Moshe Iserlles, Hagai Bergman, Natasha Hulse, Mohamed Abdelghani, Peter McGuffin, Anne Farmer, Peichel DeLea, Keyoumars Ashkan, Bernard Lerer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Subcallosal Brodmann's Area 25 (Cg25) Deep Brain Stimulation (DBS) is a new promising therapy for treatment resistant major depressive disorder (TR-MDD). While different DBS stimulating parameters may have an impact on the efficacy and safety of the therapy, there is no data to support a protocol for optimal stimulation parameters for depression. Here we present a prospective multi-center double-blind randomized crossed-over 13-month study that evaluated the effects of High (130 Hz) vs Low (20 Hz) frequency Cg25 stimulation for nine patients with TR-MDD. Four out of nine patients achieved response criteria (≥40% reduction of symptom score) compared to mean baseline values at the end of the study. The mean percent change of MADRS score showed a similar improvement in the high and low frequency stimulation groups after 6 months of stimulation (−15.4 ± 21.1 and −14.7 ± 21.1 respectively). The mean effect at the end of the second period (6 months after cross-over) was higher than the first period (first 6 months of stimulation) in all patients (−23.4 ± 19.9 (n = 6 periods) and −13.0 ± 22 (n = 9 periods) respectively). At the end of the second period, the mean percent change of the MADRS scores improved more in the high than low frequency groups (−31.3 ± 19.3 (n = 4 patients) and −7.7 ± 10.9 (n = 2 patients) respectively). Given the small numbers, detailed statistical analysis is challenging. Nonetheless the results of this study suggest that long term high frequency stimulation might confer the best results. Larger scale, randomized double blind trials are needed in order to evaluate the most effective stimulation parameters.

Original languageAmerican English
Pages (from-to)124-134
Number of pages11
JournalJournal of Psychiatric Research
StatePublished - Jan 2018

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd


  • Deep brain stimulation
  • High frequency stimulation
  • Low frequency stimulation
  • Subcallosal cingulate area
  • Treatment resistant major depressive disorder


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