Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency

Sharon Schlesinger, Eran Meshorer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Pluripotent embryonic stem cells are considered to have open and accessible chromatin relative to differentiated cells. Schlesinger and Meshorer review chromatin and epigenetic features in 2i- versus serum-grown conditions to come to a clearer picture of the genuine characteristics of pluripotency as opposed to artifacts of culture condition.

Original languageAmerican English
Pages (from-to)135-150
Number of pages16
JournalDevelopmental Cell
Volume48
Issue number2
DOIs
StatePublished - 28 Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • 2i
  • chromatin
  • chromatin plasticity
  • differentiation
  • embryonic stem cells
  • epigenetics
  • ground state
  • naive
  • nuclear plasticity
  • pluripotency
  • serum

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