Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency

Sharon Schlesinger; Eran Meshorer

doi:10.1016/j.devcel.2019.01.003

Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency

Sharon Schlesinger
, Eran Meshorer^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Abstract

Pluripotent embryonic stem cells are considered to have open and accessible chromatin relative to differentiated cells. Schlesinger and Meshorer review chromatin and epigenetic features in 2i- versus serum-grown conditions to come to a clearer picture of the genuine characteristics of pluripotency as opposed to artifacts of culture condition.

Original language	English
Pages (from-to)	135-150
Number of pages	16
Journal	Developmental Cell
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2019.01.003
State	Published - 28 Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

2i
chromatin
chromatin plasticity
differentiation
embryonic stem cells
epigenetics
ground state
naive
nuclear plasticity
pluripotency
serum

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10.1016/j.devcel.2019.01.003

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abstract = "Pluripotent embryonic stem cells are considered to have open and accessible chromatin relative to differentiated cells. Schlesinger and Meshorer review chromatin and epigenetic features in 2i- versus serum-grown conditions to come to a clearer picture of the genuine characteristics of pluripotency as opposed to artifacts of culture condition.",

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KW - epigenetics

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KW - naive

KW - nuclear plasticity

KW - pluripotency

KW - serum

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Open Chromatin, Epigenetic Plasticity, and Nuclear Organization in Pluripotency

Abstract

Bibliographical note

Keywords

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