TY - JOUR
T1 - Opposite effect of adrenalectomy on rat brain prostaglandin synthesis in basal conditions and in response to insulin or 2-deoxy-glucose
AU - Weidenfeld, J.
AU - Aburia, S.
AU - Lysy, J.
AU - Shohami, E.
PY - 1989/12
Y1 - 1989/12
N2 - In the present study we evaluated the role of endogenous glucocorticoids in the biosynthesis of prostaglandins (PG) in cortical brain tissue of the rat. Experiments were carried out under basal conditions and in response to insulin-induced hypoglycemia and 2-deoxyglucose (2-DG) induced-cytoglucopenia. In intact rats, following hypoglycemia and cytoglucopenia, the production of brain PG was decreased. These two stress stimuli also activated adrenocortical secretory responses, as manifested by an increase in circulating ACTH and corticosterone. Bilateral adrenalectomy did not modify the brain production of PG under basal conditions. In contrast, in adrenal-ectomized rats, the biosynthesis of brain cortical PG was markedly increased in response to insulin and 2-DG. These results suggest that adrenal hormones may be involved in the modulation of cortical PG production under stressful conditions.
AB - In the present study we evaluated the role of endogenous glucocorticoids in the biosynthesis of prostaglandins (PG) in cortical brain tissue of the rat. Experiments were carried out under basal conditions and in response to insulin-induced hypoglycemia and 2-deoxyglucose (2-DG) induced-cytoglucopenia. In intact rats, following hypoglycemia and cytoglucopenia, the production of brain PG was decreased. These two stress stimuli also activated adrenocortical secretory responses, as manifested by an increase in circulating ACTH and corticosterone. Bilateral adrenalectomy did not modify the brain production of PG under basal conditions. In contrast, in adrenal-ectomized rats, the biosynthesis of brain cortical PG was markedly increased in response to insulin and 2-DG. These results suggest that adrenal hormones may be involved in the modulation of cortical PG production under stressful conditions.
UR - http://www.scopus.com/inward/record.url?scp=0024848180&partnerID=8YFLogxK
U2 - 10.1016/0952-3278(89)90068-9
DO - 10.1016/0952-3278(89)90068-9
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C2 - 2560201
AN - SCOPUS:0024848180
SN - 0952-3278
VL - 38
SP - 173
EP - 176
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 3
ER -