TY - JOUR
T1 - Optical assessment of nociceptive TRP channel function at the peripheral nerve terminal
AU - Aleixandre-Carrera, Fernando
AU - Engelmayer, Nurit
AU - Ares-Suárez, David
AU - Acosta, María del Carmen
AU - Belmonte, Carlos
AU - Gallar, Juana
AU - Meseguer, Víctor
AU - Binshtok, Alexander M.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1/6
Y1 - 2021/1/6
N2 - Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP channel function is limited to data obtained from in vitro models which do not necessarily reflect physiological conditions. In recent years, the development of novel optical methods such as genetically encoded calcium indicators and photo-modulation of ion channel activity by pharmacological tools has provided an invaluable opportunity to directly assess nociceptive TRP channel function at the nerve terminal.
AB - Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP channel function is limited to data obtained from in vitro models which do not necessarily reflect physiological conditions. In recent years, the development of novel optical methods such as genetically encoded calcium indicators and photo-modulation of ion channel activity by pharmacological tools has provided an invaluable opportunity to directly assess nociceptive TRP channel function at the nerve terminal.
KW - Nociception
KW - Optical recording
KW - Opto-pharmacology
KW - Pain
KW - Peripheral nerve terminals
KW - TRP channels
UR - http://www.scopus.com/inward/record.url?scp=85099146641&partnerID=8YFLogxK
U2 - 10.3390/ijms22020481
DO - 10.3390/ijms22020481
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C2 - 33418928
AN - SCOPUS:85099146641
SN - 1661-6596
VL - 22
SP - 1
EP - 20
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 2
M1 - 481
ER -