Optical assessment of nociceptive TRP channel function at the peripheral nerve terminal

Fernando Aleixandre-Carrera, Nurit Engelmayer, David Ares-Suárez, María del Carmen Acosta, Carlos Belmonte, Juana Gallar, Víctor Meseguer*, Alexander M. Binshtok

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP channel function is limited to data obtained from in vitro models which do not necessarily reflect physiological conditions. In recent years, the development of novel optical methods such as genetically encoded calcium indicators and photo-modulation of ion channel activity by pharmacological tools has provided an invaluable opportunity to directly assess nociceptive TRP channel function at the nerve terminal.

Original languageAmerican English
Article number481
Pages (from-to)1-20
Number of pages20
JournalInternational Journal of Molecular Sciences
Volume22
Issue number2
DOIs
StatePublished - 6 Jan 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Nociception
  • Optical recording
  • Opto-pharmacology
  • Pain
  • Peripheral nerve terminals
  • TRP channels

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