TY - JOUR
T1 - Optical transmission of blood
T2 - Effect of erythrocyte aggregation
AU - Shvartsman, Leonid D.
AU - Fine, Ilya
PY - 2003/8/1
Y1 - 2003/8/1
N2 - The influence of red blood cell (RBC) aggregation on transparency of blood in the red-near infrared spectral range is investigated. We argue that for relatively thin blood layers the light diffraction on aggregates becomes the dominant phenomenon. The nature of pulsatile changes of blood transparency is explained by pulsations of RBC aggregate size. For another case of over-systolic vessel occlusion the following time evolution of blood transparency strongly depends on light wavelength. This dependence may serve as a basis for an alternative approach to noninvasive blood tests: occlusion spectroscopy. Theoretical results well correspond to both in vivo and in vitro measurements reproducing pulsatile blood flow and long occlusion as well.
AB - The influence of red blood cell (RBC) aggregation on transparency of blood in the red-near infrared spectral range is investigated. We argue that for relatively thin blood layers the light diffraction on aggregates becomes the dominant phenomenon. The nature of pulsatile changes of blood transparency is explained by pulsations of RBC aggregate size. For another case of over-systolic vessel occlusion the following time evolution of blood transparency strongly depends on light wavelength. This dependence may serve as a basis for an alternative approach to noninvasive blood tests: occlusion spectroscopy. Theoretical results well correspond to both in vivo and in vitro measurements reproducing pulsatile blood flow and long occlusion as well.
KW - Light scattering
KW - Noninvasive blood test
KW - Noninvasive glucose (hematocrit) measurement
KW - Pulse oximetry
KW - RBC aggregation
KW - Whole blood
UR - http://www.scopus.com/inward/record.url?scp=0042766844&partnerID=8YFLogxK
U2 - 10.1109/TBME.2003.814532
DO - 10.1109/TBME.2003.814532
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C2 - 12892330
AN - SCOPUS:0042766844
SN - 0018-9294
VL - 50
SP - 1026
EP - 1033
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 8
ER -