TY - JOUR
T1 - Oral absorption of biologically active insulin in common carp (Cyprinus carpio L.)
AU - Hertz, Y.
AU - Shechter, Y.
AU - Madar, Z.
AU - Gertler, A.
PY - 1992/1
Y1 - 1992/1
N2 - 1. 1. Bovine insulin dissolved in 0.05 M deoxycholic acid was absorbed through oral intubation in fish weighing 200-300 g. 2. 2. The peak of absorption appeared in all fish, 30-45 min after intubation and was followed by a gradual decrease. The extent of absorption was extremely variable, with up to a 20-fold difference between individuals. No detectable insulin was found in fish intubated with vehicle. 3. 3. The absorbed hormone retained 17-88% of its lipogenic bioaetivity in vitro. The absorbed insulin lowered the levels of several amino acids in the intubated fish, indirectly indicating that its bioactivity was also retained in vivo.
AB - 1. 1. Bovine insulin dissolved in 0.05 M deoxycholic acid was absorbed through oral intubation in fish weighing 200-300 g. 2. 2. The peak of absorption appeared in all fish, 30-45 min after intubation and was followed by a gradual decrease. The extent of absorption was extremely variable, with up to a 20-fold difference between individuals. No detectable insulin was found in fish intubated with vehicle. 3. 3. The absorbed hormone retained 17-88% of its lipogenic bioaetivity in vitro. The absorbed insulin lowered the levels of several amino acids in the intubated fish, indirectly indicating that its bioactivity was also retained in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0026527392&partnerID=8YFLogxK
U2 - 10.1016/0300-9629(92)90621-V
DO - 10.1016/0300-9629(92)90621-V
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C2 - 1347729
AN - SCOPUS:0026527392
SN - 0300-9629
VL - 101
SP - 19
EP - 22
JO - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
JF - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
IS - 1
ER -