Oral Administration of Pregabalin in Rats before or after Nerve Injury Partially Prevents Spontaneous Neuropathic Pain and Long Outlasts the Treatment Period

Ran Ran Wang, Guo Dong Lou, Jie Yu, Ting Ting Hu, Wei Wei Hou, Zhong Chen, Shi Hong Zhang, Ze'ev Seltzer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background and Methods: Pregabalin alleviates stimulus-evoked neuropathic pain (NeuP) in some pain patients and rodents in models of painful neuropathies. But it is not known if pregabalin can also alleviate spontaneous NeuP. Sciatic and saphenous neurectomy in rats elicits spontaneous self-mutilation of the denervated hindpaw, a behavior that models spontaneous NeuP. We tested if pregabalin (20 or 30 mg/kg/day; twice daily, per os) for 7 days before denervation, or 42 days thereafter, can suppress this behavior. Results: Compared with the vehicle, pregabalin administered in both treatment regimens markedly and significantly delayed autotomy onset and suppressed its levels for weeks after treatment cessation. Conclusions: At doses known to effectively suppress stimulus-evoked pain in rats, pregabalin can prevent development of spontaneous NeuP and suppress it postoperatively.

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalPharmacology
Volume97
Issue number5-6
DOIs
StatePublished - 1 Mar 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 S. Karger AG, Basel.

Keywords

  • Autotomy
  • Neuroma model
  • Palliative analgesia
  • Preemptive analgesia
  • Pregabalin
  • Spontaneous neuropathic pain

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