Oral Vancomycin and Gentamicin for Treatment of Very Early Onset Inflammatory Bowel Disease

Raffi Lev-Tzion, Oren Ledder, Eyal Shteyer, Michelle Li Nien Tan, Holm H. Uhlig, Dan Turner

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The pathogenesis of inflammatory bowel disease (IBD) is complex and involves the contribution of genetic and environmental factors. Many patients with very early onset IBD are difficult to treat. The current antibiotic medication that targets gram-negative and anaerobic bacteria provides only moderate efficacy in subsets of patients with IBD. Methods: We report a case series of 5 children with a mean age of 1.6 years (range 6 months to 2.7 years) during IBD onset, who were previously refractory to standard treatments and who received oral vancomycin with or without gentamicin. Results: Four out of 5 children demonstrated substantial therapeutic effect, and the effect was sustained in 3 children over a follow-up period of 12-33 months. Conclusion: Our findings are consistent with model systems and suggest that randomized trials are required to establish whether a change in therapeutic paradigm, that is, targeting gram-positive bacteria with nonabsorbable antibiotics, may have therapeutic benefits.

Original languageAmerican English
Pages (from-to)310-313
Number of pages4
JournalDigestion
Volume95
Issue number4
DOIs
StatePublished - 1 Jul 2017

Bibliographical note

Publisher Copyright:
© 2017 S. Karger AG, Basel.

Keywords

  • Antibiotics
  • Crohn disease
  • Primary sclerosing cholangitis
  • Ulcerative colitis

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