Oral white lesion in patients post-hematopoietic stem cell transplantation: a case series demonstrating the diagnostic dilemma

Tatsiana Pukhalskaya; Bruce R. Smoller; Michael Becker; Alexander Maly; Yehuda Zadik; Sharon Elad

doi:10.1007/s00520-021-06392-6

Oral white lesion in patients post-hematopoietic stem cell transplantation: a case series demonstrating the diagnostic dilemma

Tatsiana Pukhalskaya^*
, Bruce R. Smoller
, Michael Becker
, Alexander Maly
, Yehuda Zadik
, Sharon Elad

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The current National Institutes of Health (NIH) consensus paper excluded “white hyperkeratotic plaque” from the diagnostic criteria for oral chronic graft-versus-host disease (cGVHD) in order to ensure malignant transformation is not overlooked. Therefore, an isolated oral white plaque is recommended to be subjected to biopsy and pathologic examination. The cases described in this paper shed a new light on the clinical approach to oral white plaque post-hematopoietic stem cell transplantation. The objectives of this article are to demonstrate that a white plaque does not contradict a diagnosis of oral cGVHD, and to highlight the clinical considerations for taking a biopsy.

Original language	English
Pages (from-to)	7999-8007
Number of pages	9
Journal	Supportive Care in Cancer
Volume	29
Issue number	12
DOIs	https://doi.org/10.1007/s00520-021-06392-6
State	Published - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic GVHD
Lesion
Leukoplakia
Oral
White

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10.1007/s00520-021-06392-6

Cite this

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title = "Oral white lesion in patients post-hematopoietic stem cell transplantation: a case series demonstrating the diagnostic dilemma",

abstract = "The current National Institutes of Health (NIH) consensus paper excluded “white hyperkeratotic plaque” from the diagnostic criteria for oral chronic graft-versus-host disease (cGVHD) in order to ensure malignant transformation is not overlooked. Therefore, an isolated oral white plaque is recommended to be subjected to biopsy and pathologic examination. The cases described in this paper shed a new light on the clinical approach to oral white plaque post-hematopoietic stem cell transplantation. The objectives of this article are to demonstrate that a white plaque does not contradict a diagnosis of oral cGVHD, and to highlight the clinical considerations for taking a biopsy.",

keywords = "Chronic GVHD, Lesion, Leukoplakia, Oral, White",

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doi = "10.1007/s00520-021-06392-6",

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AU - Becker, Michael

AU - Maly, Alexander

AU - Zadik, Yehuda

AU - Elad, Sharon

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AB - The current National Institutes of Health (NIH) consensus paper excluded “white hyperkeratotic plaque” from the diagnostic criteria for oral chronic graft-versus-host disease (cGVHD) in order to ensure malignant transformation is not overlooked. Therefore, an isolated oral white plaque is recommended to be subjected to biopsy and pathologic examination. The cases described in this paper shed a new light on the clinical approach to oral white plaque post-hematopoietic stem cell transplantation. The objectives of this article are to demonstrate that a white plaque does not contradict a diagnosis of oral cGVHD, and to highlight the clinical considerations for taking a biopsy.

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KW - Lesion

KW - Leukoplakia

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KW - White

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Oral white lesion in patients post-hematopoietic stem cell transplantation: a case series demonstrating the diagnostic dilemma

Abstract

Bibliographical note

UN SDGs

Keywords

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