Orientational polarizability and stress response of biological cells

S. A. Safran*, R. De, A. Zemel

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present a theoretical treatment of the orientational response to external stress of active, contractile cells embedded in a gel-like elastic medium. The theory includes random forces as well as forces that arise from the deformation of the matrix and those due to the internal regulation of the stress fibers and focal adhesions of the cell. We calculate both the static and high frequency limits of the orientational response in terms of the cellular polarizability. For systems in which the forces due to regulation and activity dominate the mechanical forces, we show that there is a non-linear dynamical response which, in the high frequency limit, causes the cell to orient nearly perpendicular to the direction of the applied stress.

Original languageAmerican English
Title of host publicationIUTAM Symposium on Cellular, Molecular and Tissue Mechanics - Proceedings of the IUTAM Symposium
Pages91-101
Number of pages11
DOIs
StatePublished - 2010
EventIUTAM Symposium on Cellular, Molecular and Tissue Mechanics - Woods Hole, MA, United States
Duration: 18 Jun 200821 Jun 2008

Publication series

NameIUTAM Bookseries
Volume16
ISSN (Print)1875-3507

Conference

ConferenceIUTAM Symposium on Cellular, Molecular and Tissue Mechanics
Country/TerritoryUnited States
CityWoods Hole, MA
Period18/06/0821/06/08

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