Origins and tissue-context-dependent fates of blood monocytes

Chen Varol, Simon Yona, Steffen Jung*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations

Abstract

Peripheral blood monocytes play a central role in the mononuclear phagocyte system by providing a critical link between the bone marrow (BM), as major site of adult hematopoiesis, and peripheral, terminally differentiated mononuclear phagocyte populations, as represented macrophages and dendritic cells. Moreover, recent experimental evidence highlights the plasticity of these ephemeral mobile cells and their direct involvement in the establishment and resolution of inflammatory reactions. Here we summarize the recent advance in our understanding of monocyte origins, subset dynamics and monocyte fates. In particular, we will focus on emerging evidence for monocyte recirculation to the BM and discuss its potential implications in health and disease.

Original languageAmerican English
Pages (from-to)30-38
Number of pages9
JournalImmunology and Cell Biology
Volume87
Issue number1
DOIs
StatePublished - 16 Jan 2009
Externally publishedYes

Keywords

  • Dendritic cells
  • MDP
  • Macrophages
  • Monocytes

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